ABSTRACT
How to cite this article: Sampley S, Bhasin D, Singh H, Mishra S. Cerebral Aspergillosis Complicating COVID Recovery. Indian J Crit Care Med 2022;26(4):535–536.
ABSTRACT
Viruses represents the most teeming biological organisms on earth.1 They are responsible for killing approximately twenty percent of the microbial biomass in oceans per day. 2 In the recent decade, there have been alarming outbreaks of several viruses like Zika virus, Ebola virus, Severe Acute Respiratory Syndrome Corona virus (SARS-CoV), Middle East Respiratory Syndrome Corona virus (MN1 -https://media.proquest.com/media/hms/PFT/1/P8cxM?_a=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%2BgIBToIDA1dlYooDHENJRDoyMDIyMDUyMDE0MDUzNTQ4OTo3MzQyMjA%3D&_s=VYWo4U332I0foU2CCBjSnuDP%2BCo%3D ERS -CoV) and now a novel corona virus.3 This article provides a basic understanding of SARS- COV-2 virus and overview of plausible mechanism of Chloroquine / Hydroxychloroquine in management of COVID-19. In year 2019, in Wuhan (Province of China), a novel corona virus was first detected.4 In February 2020, it was assigned the name COVID-19 by World Health Organization and on 11th March,2020 it was declared a pandemic.5 The corona virus study group of the International Committee on Taxonomy of Viruses (ICTV) has named it Severe Acute Respiratory Syndrome Corona virus 2 (SARS-COV-2).6 Three pandemics have been caused by corona viruses-SARS-CoV, MERS- CoV and SARS-CoV-2.3 In spite of all the necessary measures taken to halt this emerging virus, it has spread worldwide.7 Due to pandemic, astronomical efforts are going on to search molecules effective against SARS-CoV-2. Some like MERS-CoV binds to Dipeptidyl-peptidase- 4(DPP-4) to enter host cells while SARS-CoV binds regions of Angiotensin Converting Enzyme-2 (ACE-2) which is a zinc binding carboxypeptidase enzyme responsible for regulation of cardiac function and blood pressure.15 ACE-2 is expressed in epithelial cells of the lungs and small intestine as well as many other organs. [...]chloroquine and hydroxychloroquine are concentrated within endosomes, golgi vesicles and lysosomes where pH is acidic.
ABSTRACT
How to cite this article: Sampley S, Bhasin D, Singh H, Mishra S. Cerebral Aspergillosis Complicating COVID Recovery. Indian J Crit Care Med 2022;26(4):535-536.